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CYP3A4 inducers could increase the development on the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely observe clients taking ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.pentobarbital will lessen the extent or result of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Us